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Head and neck cancer

Cancers that are known collectively as head and neck cancers usually begin in the squamous cells that line the moist, mucosal surfaces inside the head and neck (for example, inside the mouth, the nose, and the throat). These squamous cell cancers are often referred to as squamous cell carcinomas of the head and neck. Head and neck cancers can also begin in the salivary glands, but salivary gland cancers are relatively uncommon. Salivary glands contain many different types of cells that can become cancerous, so there are many different types of salivary gland cancer.

Causes

Alcohol and tobacco use (including smokeless tobacco, sometimes called “chewing tobacco” or “snuff”) are the two most important risk factors for head and neck cancers, especially cancers of the oral cavity, oropharynx, hypopharynx, and larynx (2–5). At least 75% of head and neck cancers are caused by tobacco and alcohol use. People who use both tobacco and alcohol are at greater risk of developing these cancers than people who use either tobacco or alcohol alone (6–8). Tobacco and alcohol use are not risk factors for salivary gland cancers.

Infection with cancer-causing types of human papillomavirus (HPV), especially HPV type 16, is a risk factor for some types of head and neck cancers, particularly oropharyngeal cancers that involve the tonsils or the base of the tongue (9–11). In the United States, the incidence of oropharyngeal cancers caused by HPV infection is increasing, while the incidence of oropharyngeal cancers related to other causes is falling.

Symptoms

Some common symptoms of head and neck cancer tumors include:

  • A lump in the nose, neck or throat, with or without pain
  • A persistent sore throat
  • Trouble swallowing (dysphagia)
  • Unexplained weight loss
  • Frequent coughing
  • Change in voice or hoarseness
  • Ear pain or trouble hearing
  • Headaches
  • A red or white patch in the mouth
  • Bad breath that's unexplained by hygiene
  • Nasal obstruction or persistent congestion
  • Frequent nose bleeds or unusual discharge
  • Trouble breathing
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